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Deficient Butyrate-Producing Capacity in the Gut Microbiome of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Is Associated with Fatigue Symptoms

• Published: 2021

• Source: medRxiv (preprint)

• Focus: Investigated the gut microbiome's butyrate-producing capacity in ME/CFS patients and its association with fatigue severity.

• Study Design: Case-control study involving 106 ME/CFS patients and 91 healthy controls across the United States.

• Findings: ME/CFS patients exhibited decreased relative abundance and quantity of butyrate-producing bacteria, including *Faecalibacterium, *Roseburia, and *Eubacterium species. This deficiency correlated with increased fatigue severity.

• Key Bacterial Imbalances: Reduced levels of *Faecalibacterium, *Roseburia, and *Eubacterium species.

 

Reduced Diversity and Altered Composition of the Gut Microbiome in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

• Published: 2016

• Source: Microbiome

• Focus: Assessed gut microbiota diversity and composition in ME/CFS patients compared to healthy individuals.

• Study Design: Comparative analysis of gut microbiota between 48 ME/CFS patients and 39 healthy controls.

• Findings: ME/CFS patients showed reduced gut microbiota diversity and altered composition, with decreased abundance of anti-inflammatory bacteria like *Faecalibacterium. 

• Key Bacterial Imbalances: Decreased *Faecalibacterium.

 

Altered Gut Microbiota and Intestinal Permeability Correlate with Fatigue in Patients with Major Depressive Disorder

• Published: 2017

• Source: Brain, Behavior, and Immunity

• Focus: Explored the relationship between gut microbiota composition, intestinal permeability, and fatigue severity in patients with Major Depressive Disorder (MDD).

• Study Design: Cross-sectional study involving 44 MDD patients and 44 healthy controls.

• Findings: MDD patients with high fatigue levels exhibited increased intestinal permeability and altered gut microbiota, including reduced abundance of *Faecalibacterium.

• Key Bacterial Imbalances: Decreased *Faecalibacterium .

 

Gut Microbiota Composition and Fatigue During the First Year of Multiple Sclerosis

• Published: 2020

• Source: Multiple Sclerosis Journal

• Focus: Investigated the association between gut microbiota composition and fatigue severity in early Multiple Sclerosis (MS) patients.

• Study Design: Longitudinal study of 101 early MS patients over one year.

• Findings: Patients with higher fatigue levels had reduced abundance of short-chain fatty acid-producing bacteria, including *Faecalibacterium , suggesting a link between gut dysbiosis and fatigue in MS.

• Key Bacterial Imbalances: Decreased *Faecalibacterium.

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* The Comprehensive Gut Analysis tests for Faecalibacterium.

 

 

A gut analysis is not designed to diagnose, prevent, or treat any diseases. If you have been diagnosed with a chronic medical condition and have already  received specific dietary recommendations or prescription medication from your doctor this test is not recommended for you due to the risk of nutrients/supplement and drug interactions.

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